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After a century of friendship, smoking opium with Genghis Khan and having orgies in Michelangelo’s studio, two inseparable vampire buddies are on the verge of splitting up. Terrible timing, as an apocalypse-obsessed villain is plotting an end to humanity. Looks like Nick and Tree, immortal best buds getting by as bail bondsmen, are humanity’s last hope… Can they put their baggage aside long enough to save the world?