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At the heart of Věc Makropulos is a recipe for a life-prolonging elixir invented by the doctor Hieronymus Makropulos for Emperor Rudolf II. It was tested on the doctor's beautiful daughter, who has now been on earth for 337 years and has had countless affairs over the generations. In the end, however, the seemingly young woman has to realize that an endless life on this side of the world only brings loneliness.