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Salvo and Valentino are two Sicilian nurses working in a Milan clinic, commuting between Sicily and Milan on low-cost flights. Their medical director, a Calabrian who pretends to be Milanese, constantly hinders their attempts to return home. One night, thanks to a wish made by Valentino's daughter, they discover a magical dumpster that teleports them from Piazza del Duomo in Milan to their hometown in Sicily, and back again.