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In a luxurious hotel in Naples, there is something magical and mysterious about room 52. The only person aware of this is Serena, an eccentric fifty-year-old chambermaid who still has a smile on her face despite a difficult life. As she cleans, Serena asks the room about the fate of her deceased husband in the afterlife and the room appears, somewhat confusedly, to answer her. A surreal dialogue ensues, during which Serena talks about her own and other people’s sins, and frankly tackles a fundamental theme of Christian morality.