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Examines the 20 of the most shocking unsolved crimes in history including the disappearance of Adam Walsh, the murder of Jam-Master Jay, the murders of Jason Allen and Lindsay Cutshall, the Tylenol Poisoning scare, the mysterious death of musician Bobby Fuller, the Zodiac Killer, the assassination of spy Alexander Litvinenko, the murder of Vanessa Johnson, the murder of Amber Hagerman, the Isabella Stewart Gardner Museum Robbery, the disappearance of George Allen Smith, disappearance of heiress Jacqueline Levitz, the disappearance of Madeleine McCann, the 2001 Anthrax attacks, the D.B Cooper skyjacking, the murder of Chandra Levy, the disappearance of Jimmy Hoffa, the murder of the Black Dahlia, the murder of JonBenet Ramsey, and the disappearance of Natalee Holloway.