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Nanotechnology researcher Wang Miao is taken to the Joint Operations Center by police officer Shi Qiang, who's investigating the mysterious suicide wave among scientists worldwide, and recruited to sneak into an organization called the Frontiers of Science to help the investigation. When Wang Miao is contacted by the leader of the organization, Shen Yufei, she introduces him to a sophisticated VR video game called Three-Body, but soon he discovers that it's more than just a game.