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The story is set in Sumidagawa Hospital, an emergency hospital in downtown Tokyo. The head of surgery there, Iwashita Ken, is a brain surgeon who has just returned from the United States . He has excellent skills, but his strict personality often makes him the envy of other doctors. He also has a secret past. The story depicts the various facets of the hospital, including the interactions between doctors and patients, the power struggle within the hospital, and Asou Yukie, a recent nursing school graduate who was assigned to the hospital unaware of the complex internal affairs that exist.