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Pablo Escobar was the most notorious, but there was also Toto Riina in Sicily, Khun Sa in the Golden Triangle, and Felix Gallardo in Mexico, all of whom changed the destinies of their respective territories by taking drug trafficking to a global scale. They defied states and threatened the powers-that-be. It took almost 20 years for states to get organized and come up with strategies to bring down the drug barons.