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The Medici family dominated politics and the economy in Renaissance Florence. To break the Medici influence, the old-established Pazzi family attempts to assassinate brothers Giuliano and Lorenzo de Medici. They succeed only partially, leading to the capture of the perpetrators and a search for the conspirators. In a present-day investigation, Florence Kasumba together with historians such as Marcello Simonetta gathers clues from medicine, psychology, and art history.